| Variable | Response |
|---|---|
| Full Name | Sydney Memory and Ageing Study |
| CRS Continents(s) | Australia |
| CRS ID | 101 |
| Acronym | MAS |
| Low-Middle Income Country | No |
| Data Available Through DPAU | Yes |
| Follow-Up Data Available | Yes |
| CRS Overview | The aim of the Memory and Ageing Study (MAS) was initiated in 2005 to examine the clinical characteristics and prevalence of mild cognitive impairment (MCI) and related syndromes and to determine the rate of change in cognitive function and incident dementia over time. MAS uses epidemiological, neuropsychiatric, biospecimen and neuroimaging data to understand various factors associated with both healthy cognitive ageing and cognitive decline. In recent years, a major aim of the study has become identifying modifiable lifestyle factors associated with brain health in older age. At baseline, participants were 1037 older Australians aged 70-90 years old who took part in detailed neuropsychiatric and medical assessments and donated a blood sample for clinical chemistry, proteomics and genomics. A knowledgeable informant was also interviewed at each Wave. Participants and informants were followed up biennially - called Waves - for 15-years (7 Waves). |
| No. of Subjects at Baseline | 1037 |
| Institution | University of New South Wales (UNSW Sydney) |
| Department Name | Centre for Healthy Brain Ageing (CHeBA) |
| City | Sydney |
| Country | Australia |
| Study/Database Website | https://cheba.unsw.edu.au/research-projects/sydney-memory-and-ageing-study |
| Principal Investigator (PI) | Professor Henry Brodaty and Professor Perminder Sachdev |
| PI email | h.brodaty@unsw.edu.au; p.sachdev@unsw.edu.au |
| Key Study References | Sachdev, P. S., Brodaty, H., Reppermund, S., Kochan, N. A., Trollor, J. N., Draper, B., ... & Lux, O. (2010). The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70-90 years. International psychogeriatrics, 22(8), 1248. |
| Population Based Study? | Yes |
| Family Based Study? | No |
| Clinical Based Sample? | No |
| Were participants included prior to development of dementia (may refer to controls only)? | Yes |
| Were participants included prior to development of MCI (may refer to controls only)? | Yes |
| How is data collected? | Participants: telephone interviewed, face-to-face assessment including medical examination, and self-report questionnaires.; Informant: telephone interviewed and self-report questionnaires. |
| Who carries out data collection? | Research psychology graduates |
| Does this take place in participants' homes or at a central location? | Participants were assessed at either a study centre or in their own home if they were unable to visit the centre for face-to-face assessment. |
| Do participants take part individually or are families/partners involved? | Family/partner (informant) involved |
| Dementia cases ascertained as part of study | Yes |
| Diagnosis based on review of existing clinical data | Yes |
| Were diagnosis/primary outcomes made blind to exposure variables? | Not Applicable |
| How many times followed up? | 7 |
| Sample Size at Follow-Up | Wave 1 = 1037 Wave 2 = 889 Wave 3 = 792 Wave 4 = 708 Wave 5 = 569 Wave 6 = 475 Wave 7 = 258 |
| Study start date | 2005 |
| Study end date | 2020 |
| Study Timeline | Wave 1: Sep 2005 - Dec 2007 Wave 2: Oct 2007 - Dec 2009 Wave 3: Oct 2009 - Dec 2011 Wave 4: Oct 2011 - Mar 2014 Wave 5: Oct 2013 - Mar 2016 Wave 6: Mar 2016 - Aug 2018 Wave 7: Sep 2018 - Dec 2020 |
| Is data collection still ongoing? | No |
| Is study still recruiting? | No |
| Inclusion criteria | Participants aged 70-90 years living in the community were randomly selected to participate. They needed to speak and write English sufficiently well to complete a psychometric assessment and were able to consent to participate. The majority of participants (93.9%) had an informant who was the closest person to them and preferably someone who cohabitated with them. The informant had to know the participant well enough to be able to answer questions about the participant's memory, thinking, and daily functions. The informant had to have at least weekly contact of not less than one hour with the participant. |
| Exclusion criteria | Participants were excluded if they had a previous diagnosis of dementia, psychotic symptoms or a diagnosis of schizophrenia or bipolar disorder, multiple sclerosis, motor neuron disease, developmental disability, progressive malignancy (active cancer or receiving treatment for cancer, other than prostate -non-metastasized, and skin cancer), or if they had medical or psychological conditions that may have prevented them from completing assessments. Participants were excluded if they had a Mini-mental Statement Examination (MMSE; (Folsteinet al., 1975) score of<24 adjusted for age, education and non-English speaking background (Andersonet al., 2007) at study entry, or if they received a diagnosis of dementia after comprehensive assessment. |
| Minimum Age | 70 |
| Sex Included in Study | Male and Female |
| Are there likely to be updates or revisions to the data after its release? | Yes |
| Notes | Genetics/epigenomics and imaging data are not available on DPAU but can be applied through CHeBAData@unsw.edu.au. |
| Publications | |
| Documents | |
| Data Availability | Full data available on DPAU |
| Data Access Process | Application through DPAU |
| Data Distribution Rule | By Ontology |
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